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CytoQuest™ CR - Circulating Rare Cell Positive Enrichment & Retrieval System

Abnova’s CytoQuest™ CR is a non-invasive system for capture, enumeration, isolation and retrieval of circulating rare cells (CRCs). Three major subtypes of CRCs in translational research and clinical studies are circulating tumor cells (CTCs), circulating progenitor cells (CPCs), and circulating fetal cells (CFCs). A challenge for market adoption of CRCs is the efficient and reproducible identification, single cell isolation, and retrieval of highly pure and viable CRCs, with their applications supported by a wide repertoire of standardized, GMP grade bioreagents.

CytoQuest™ CR technology utilizes SCx™ spiral chamber, HBx™ micromixer, antibody immobilized nanoarray, and TCx™ thermal control to enable a multitude of CRC functions. SCx™ spiral chamber is equipped with a non-sticky coil and a self-contained micro-vibrator for unimpeded delivery of pretreated blood sample into the nanoarray. HBx™ micromixer provides a herringbone conduit for cell mixing. CytoChipNano is a streptavidin nanoarray which captures the CRCs for cell enumeration and single cell isolation by laser microdissection or micromanipulation. CytoChipNano CR is a specialized streptavidin nanoarray with thermo-sensitive coating which captures and releases the CRCs via a TCx™ thermal control of alternating temperatures.

Monoclonal antibodies targeting specific surface biomarkers of circulating rare cells can be flexibly interchanged to accommodate the biomarker switch in CRC progression. This results in highly pure and viable CRCs for downstream protein characterizations, gene analyses, and cell assays. Cell enumeration is currently the only FDA approved application as a prognostic marker in breast, prostate, and colorectal cancers. In contrast, effective single cell isolation and retrieval of CRCs opens up new scope of applications in the diagnostic and pharmaceutical industry.

 

Overview

Catalog # : M0014-04
Price: Please Inquire
Regulatory Status : CE-IVD
Subtypes of CRCs

  • Circulating Tumor Cells (CTCs)
  • Circulating Progenitor Cells (CPCs)
  • Circulating Fetal Cells (CFCs)
Applications of CTCs

Protein Characterizations
  • Immunofluorescence
  • Proximity ligation assay (PLA)
Gene Analyses
  • Fluorescent In Situ Hybridization (FISH)
  • Polymerase Chain Reaction (PCR)
      Gene Amplifications (GAs)
      Somatic Mutations (SMs)
      Single Nucleotide Polymorphisms (SNPs)
  • Comparative Genomic Hybridization (CGH)
      Copy Number Variants (CNVs)
  • Next Generation Sequencing (NGS)
Cell Assays
  • Primary cell line construction
  • Compound screening
Advantages of CytoQuest™ CR Platform

Integrated system
  • Bottle reservoir
  • Fluidic handler
  • SCx™ spiral chamber
  • TBx™ tension balancer
  • Coupler
  • HBx™ micromixer
  • Chip receptor
  • TCx™ thermal chuck
  • Touch user interface
Antibody-based, cell capture
  • Cell enumeration (CytoChipNano)
  • Single cell isolation (CytoChipNano)
  • Thermal cell release (CytoChipNano CR)

CytoQuest™ CR                     

Buffer Reservoir
Bottle Reservoir
Fluidic
Fluidic Handler
Chamber
SCx™ Spiral
Chamber
Spiral Chamber Holder
Spiral Chamber Holder
TBx™ Tension Balancer
TBx™ Tension Balancer
Coupler
Coupler
Chip Receptor
Chip Receptor
Micromixer
HBx™ Micromixer
CytoChipNano
CytoChipNano
CytoChipNano CR
CytoChipNano
CR
TCx™ Thermal Chuck
TCx™ Thermal
Chuck
Chip Opener
Chip Opener
Temperature
Temperature Display
QR Code Scanner
QR Code Scanner
Power On LED
Power On LED
Touch User Interface
Touch User 

 

Specifications

Hardware General Specifications

Dimensions: 565.06mm(h) x 340.8mm(d) x 271.8mm(w)
Weight: 18 kg
Power: Fluidic Handler: 100-240VAC, 50/60Hz,1.6A
Thermal Controller: 100-240VAC, 50/60Hz, 4.0A
Replace Fuse: Fluidic Handler: 1.6A(Peak)/250V
Thermal Controller: 4A (Peak)/250V
Operating Temperature: 60°F to 104°F (15°C to 40°C)
Programable Thermo Control Profile: 4-40°C, Variable Time Span
Hardware Environmental Specifications

Storage Temperature: -5°F to 158°F (-20°C to 70°C)
Operation Altitude: Up to 2000m
Operation Environment: For indoor use
Operating Humidity: 20% to 90% Relative Humidity, Non-Condensing
Storage Humidity: 20% to 95% Relative Humidity, Non-Condensing
Software Specifications

Scanner Function: Scanning Capability to Read QR Code/Barcode
Status Display: Progress and Fluid Handling
System Clean: Prime and Clean
Report Generation: Print and Export File
Touchscreen Laptop Specifications

Operating System: Windows 7/8/10 (32-bit and 64-bit)
Processor: Pentium III/Celeron 866 MHz or Equivalent
Memory: 1GB Minimum (2GB Recommended)
Free Disk Space: 4GB
Interfaces/USB Ports: USB 2.0 Port*1
 

Catalog # : M0014-04
Price: Please Inquire
Regulatory Status : CE-IVD
Subtypes of CRCs

  • Circulating Tumor Cells (CTCs)
  • Circulating Progenitor Cells (CPCs)
  • Circulating Fetal Cells (CFCs)
Applications of CTCs

Protein Characterizations
  • Immunofluorescence
  • Proximity ligation assay (PLA)
Gene Analyses
  • Fluorescent In Situ Hybridization (FISH)
  • Polymerase Chain Reaction (PCR)
      Gene Amplifications (GAs)
      Somatic Mutations (SMs)
      Single Nucleotide Polymorphisms (SNPs)
  • Comparative Genomic Hybridization (CGH)
      Copy Number Variants (CNVs)
  • Next Generation Sequencing (NGS)
Cell Assays
  • Primary cell line construction
  • Compound screening
Advantages of CytoQuest™ CR Platform

Integrated system
  • Bottle reservoir
  • Fluidic handler
  • SCx™ spiral chamber
  • TBx™ tension balancer
  • Coupler
  • HBx™ micromixer
  • Chip receptor
  • TCx™ thermal chuck
  • Touch user interface
Antibody-based, cell capture
  • Cell enumeration (CytoChipNano)
  • Single cell isolation (CytoChipNano)
  • Thermal cell release (CytoChipNano CR)

CytoQuest™ CR                     

Buffer Reservoir
Bottle Reservoir
Fluidic
Fluidic Handler
Chamber
SCx™ Spiral
Chamber
Spiral Chamber Holder
Spiral Chamber Holder
TBx™ Tension Balancer
TBx™ Tension Balancer
Coupler
Coupler
Chip Receptor
Chip Receptor
Micromixer
HBx™ Micromixer
CytoChipNano
CytoChipNano
CytoChipNano CR
CytoChipNano
CR
TCx™ Thermal Chuck
TCx™ Thermal
Chuck
Chip Opener
Chip Opener
Temperature
Temperature Display
QR Code Scanner
QR Code Scanner
Power On LED
Power On LED
Touch User Interface
Touch User 

Our Partners

Address

Bio-Active Co., Ltd. 
188/1 Bio-Active Bldg., Soi Sirung,
Chua Phloeng Rd., Chongnonsi,
Yannawa Bangkok 10120 
Thailand

 

ที่อยู่

บริษัท ไบโอแอคทีฟ จำกัด
188/1 อาคารไบโอแอคทีฟ ซอยศรีรุ้ง
ถนนเชื้อเพลิง แขวงช่องนนทรี
เขตยานนาวา กรุงเทพฯ 10120

Phone

  • Hot line: 66-2350-3090
    FAX : 66-2350-3080

 

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